Mal-PEG-NH2 (maleimide-polyethylene glycol-amino)—focus on PEG derivatives

Mal-PEG-NH2, or Maleimide-PEG-Amine, is a polyethylene glycol (PEG) derivative with unique chemical properties. Its molecular structure contains maleimide and amine groups (NH2), which enable it to react chemically with a variety of molecules and biological matrices to form stable thioether and amine bonds.

The maleimide group can react with thiol to form a stable thioether bond at a pH of 6.5 to 7.5. This reaction is widely used in the biomedical field to prepare functional materials and drug delivery. In addition, the amine group is located at the other end of the Mal-PEG-NH2 molecule and can react with many other amine-active molecules, such as N-hydroxysuccinimide (NHS) and carboxylic acid (-COOH).

Mal-PEG-NH2 has a wide range of applications, the most common of which are surface modification and bioconjugation. Functional materials such as modified nanoparticles, biochips, drug carriers, etc. can be prepared by the reaction of maleimide with thiol. In addition, amine groups can react with active groups such as carboxyl and hydroxyl groups in biomolecules, thereby achieving effective targeting and delivery of biomolecules.

Mal-PEG-NH2, where "NH2" represents amine groups, "PEG" represents polyethylene glycol, and "MAL" represents maleimide groups. The molecular weight can be different values, such as 1K, 2K, 3.4K, 5K, 6K, 7.5k, 8k, 10K, 20K, etc. The end group substitution rate is generally greater than or equal to 95%, which indicates the successful synthesis rate of maleimide groups and amine groups.

In general, Mal-PEG-NH2 is a functional polyethylene glycol derivative with broad application prospects.

【Product Information】

English name: NH2-PEG-MAL

Amine-PEG-Maleimide

Molecular weight: 1K, 2K, 3.4K, 5K, 6K, 7.5k, 8k, 10K, 20K

Purity: ≥95%