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Coating agents play a vital role in drug formulation by improving stability, controlling release, and masking unpleasant tastes. These specialized materials protect active ingredients from degradation while optimizing drug delivery.
Coating Type | Primary Function | Typical Use Cases |
---|---|---|
Film coatings | Moisture protection, swallowability | Tablets, capsules |
Enteric coatings | Delayed release (pH-dependent) | Acid-sensitive drugs |
Sustained-release | Controlled drug delivery | Extended therapy |
Sugar coatings | Taste masking, appearance | Pediatric medicines |
Property | Film Coatings | Enteric Coatings | Sustained-Release | Sugar Coatings |
---|---|---|---|---|
Dissolution Time | 15-30 min | 2-6 hours | Hours to days | Immediate |
Moisture Protection | High | Very High | Moderate | Low |
Taste Masking | Good | Excellent | Fair | Excellent |
Process Complexity | Low | Moderate | High | Very High |
Factor | Consideration |
---|---|
Drug stability | Protection from light/moisture |
Release profile | Immediate or modified release |
Patient compliance | Taste/size/swallowability |
Manufacturing | Process scalability |
Parameter | Optimal Range | Impact on Quality |
---|---|---|
Spray Rate | 5-20 g/min | Uniformity |
Inlet Air Temp | 40-70°C | Drying efficiency |
Pan Speed | 8-20 rpm | Coating distribution |
Atomization Pressure | 1.5-3 bar | Droplet size |
Modern coating innovations include:
Pharmaceutical coating agents are essential for developing effective, patient-friendly medications. The right coating selection depends on drug properties, desired release profile, and manufacturing requirements. As drug delivery systems advance, coating technologies continue to evolve with smarter functionality.
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