813-94-5 - Names and IdentifiersNameCalcium Citrate anhydrousSynonymscitricalacicontralCalsium
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| Name | Calcium Citrate anhydrous |
| Synonyms | citrical acicontral Calsium citrate Calcium citrate CALCIUM(II) CITRATE tricalcium dicitrate tribasiccalciumcitrate Citric acid calcium salt Calcium citrate tribasic Calcium Citrate anhydrous citric acid sesquicalcium Tricalcium Citrate anhydrous supply good quality calcium citrate |
| CAS | 813-94-5 |
| EINECS | 212-391-7 |
| InChI | InChI=1/2C6H8O7.3Ca/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6 |
| Molecular Formula | C12H10Ca3O14 |
| Molar Mass | 498.43 |
| Solubility | 1M HCl |
| Appearance | White to beige powder |
| Storage Condition | Room Temprature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Physical and Chemical Properties | White powder, soluble in water, difficult to dissolve in ethanol, due to the presence of trace amount of calcium hydroxide, the aqueous solution was slightly turbid and gradually lost when heated to 100 ℃, 120 ℃ completely lost. |
| Use | Chelating agents, buffers, tissue coagulants, calcium fortifiers, emulsifying salts. |
| WGK Germany | 1 |
| calcium supplement preparation | inorganic calcium: calcium carbonate, calcium oxide (active calcium), calcium chloride, calcium hydrogen phosphate as the main functional components. Organic calcium: Calcium gluconate, calcium lactate, calcium citrate, calcium acetate. Calcium amino acid is a new calcium source, which is also organic calcium in terms of its chemical molecular composition, such as: calcium L-threonate, acid chelated calcium. How much calcium can be absorbed by the body is the most concerned. The absorption rate test showed that different calcium preparations containing 250 mg of elemental calcium were taken at the same time with a standardized breakfast, and the absorption rates were: malic acid, calcium citrate salt 35%, calcium carbonate salt 27%, calcium phosphate salt 25%, the effect of calcium supplementation was not significant, but calcium carbonate was the most cost-effective. |
| side effects | calcium citrate is a calcium salt derived from citric acid, a nutritional supplement for the prevention and treatment of calcium deficiency, it can promote the health of teeth and bones, and help to lose weight. Because it is soluble in water, it is the most easily absorbed calcium by the human body. Although there are many benefits, but there are also some side effects. Common side effects include bloating, constipation, and hiccups. If symptoms such as constipation, Nausea, Vomit, dry mouth or decreased appetite occur after taking calcium citrate, it should be stopped immediately and contact the doctor in time. Serious side effects include Dyspnea, difficulty swallowing, bone or Myalgia, severe weight loss, frequent urination, thirst, irregular heart rate and weakness, etc. |
| interacting agents | Tetracycline antibiotics, oxytetracycline, doxycycline, vitamin D supplements, Antacids containing aluminum or calcium. |
| identification test | take a sample of TS-158 mg and dissolve it in 10ml of water and ML of dilute nitric acid test solution, add 1 ml of mercury sulfate solution (TS-142), heat to boiling, and add potassium permanganate solution (TS-193). A white precipitate should be formed. 500mg of the sample was completely burned at the lowest possible temperature. After cooling, the residue was dissolved in 10ml of water and 1 ml of glacial acetic acid. After filtration, 10ml of ammonium oxalate test solution (TS-24) was added to the filtrate. A large amount of white precipitate soluble in hydrochloric acid should be formed. The infrared spectrum shall be in accordance with figure 06002. |
| content analysis | accurately weigh about 350mg of sample pre-dried at 150 ℃ for 4H, dissolve in 10ml water and 2ml dilute hydrochloric acid test solution (TS-117), dilute to about ml with water. Under stirring (preferably with a magnetic stirrer), add 0.05mol/L disodium EDTA about 30ml from a 50ml burette, then add 15ml of sodium hydroxide solution (TS-224) and 300mg of hydroxynaphthol blue indicator, titration was continued to the blue end point. Per Ml,0.05mol/L disodium EDTA is equivalent to calcium citrate [Ca3(C6H5O7)2]8.300mg. |
| toxicity | ADI is not specified (FAO/WHO,2001). No toxicity was actually shown. See citric acid ". GRAS(FDA,§ 182.1195,§ 182.5195,§ 182.6195,§ 182.8195,2000). |
| Use limit | GB 14880-94: cereals and their products, beverages, 8-16 g/kg. GB 2760 a 2000: soft drinks 0.44~3.7g/kg. FAO/WHO(1984,g/kg): low times concentrated milk, sweet condensed milk, cream, etc., single use 2, combined with other stabilizers 3 (anhydrous); Milk powder, cream Powder 5 (in anhydrous terms); Melted cheese manufacturing 40; Jam and jelly to maintain a pH of 2.8~3.5; Tomato canned for 800mg/kg, whole package is 450mg/kg (Ca); Cold drinks, caseinate, according to GMP. When used as a fortifier, the theoretical calcium content of this product is 21.07%, which can be used for flour, cakes, Japanese fermented soybean paste, etc. Japan Limited: ≤ 1% (Ca; Excluding special nutritious food). |
| Use | calcium citrate as a dietary calcium fortifier has better absorption effect than inorganic calcium. China's provisions can be used for cereals and their products, the use of 8~16 g/kg in milk drinks and drinks for 1.8~3.6g/kg. used as chelating agent, buffer, tissue coagulant, calcium fortifier, emulsifying salt, etc. chelating agent, buffer, tissue coagulant, according to FAO/WHO(1984), uses and limits are: low times concentrated milk, sweetened condensed milk, cream and so on single use 2G/kg, and other stabilizer dosage 3g/kg (based on Anhydrous); Milk powder, cream powder 5g/kg; melt dry manufacturing 40g/kg; Jelly, canned tomato, cold drinks, cold protein salt, according to GMP as a fortifier, the theoretical calcium content of the product is 21.07%, can be used for flour, cakes, japanese fermented soybean paste, Japan limited to 1%. calcium citrate is a calcium salt derived from citric acid. It is a nutritional supplement for the prevention and treatment of calcium deficiency. |
| production method | The citric acid solution was neutralized with milk of lime and reacted to form a precipitate, which was filtered, washed and dried to obtain a finished product. Eggshell can also be used as raw material, after cleaning, crushing, water immersion washing, drying, and then drying at 110 1H, and then calcined at 1000 1H, add water to make milk of lime; then neutralized with 3.5~4.0mol/L citric acid solution (citric acid slightly excess), and then precipitated, filtered, washed with water to Ph = 6~7, the final product was dried at 110 °c for 1H. The citric acid aqueous solution is neutralized with lime or calcium carbonate, and the resulting precipitate is filtered, washed, and dried. Alternatively, calcium chloride is added to an aqueous solution of sodium citrate. |
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