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5-chloro-2-methylaniline

5-Chloro-2-methylaniline (CAS 95-79-7) is an important chemical compound used in various industrial

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5-Chloro-2-methylaniline (CAS 95-79-7) is an important chemical compound used in various industrial applications. This article provides a comprehensive overview of its properties, synthesis, applications, and safety considerations.

Table 1: Basic Properties of 5-Chloro-2-Methylaniline

PropertyDescription
Molecular FormulaC7H8ClN
Molecular Weight141.60 g/mol
AppearanceWhite crystalline solid
Melting Point52-54°C
Boiling Point215°C
SolubilitySlightly soluble in water, soluble in organic solvents

5-Chloro-2-methylaniline is a white crystalline solid with a melting point of 52-54°C and a boiling point of 215°C. It is slightly soluble in water but readily dissolves in organic solvents.

Table 2: Synthesis of 5-Chloro-2-Methylaniline

StepProcessReagents
Starting MaterialAniline-
ChlorinationElectrophilic substitutionChlorine gas or chlorinating agents
MethylationNucleophilic substitutionMethyl iodide, base (e.g., NaOH)

The synthesis of 5-Chloro-2-methylaniline typically involves the chlorination of aniline followed by methylation. Chlorination introduces the chlorine atom at the para position, while methylation adds a methyl group at the ortho position.

Table 3: Applications of 5-Chloro-2-Methylaniline

ApplicationDescription
PharmaceuticalsIntermediate for drug synthesisAntidepressants, antihistamines
Dyes and PigmentsPrecursor for azo dyesRed and yellow dyes
AgrochemicalsIntermediate for pesticide synthesisHerbicides, insecticides
Chemical SynthesisBuilding block for complex moleculesResearch and industrial applications

5-Chloro-2-methylaniline is a versatile intermediate used in the synthesis of pharmaceuticals, dyes, agrochemicals, and other complex chemical compounds. Its functional groups make it suitable for various chemical reactions.

Table 4: Safety and Handling Considerations

AspectDescription
ToxicityToxic if inhaled or ingestedCauses irritation to eyes, skin, and respiratory tract
FlammabilityFlammable liquid and vaporKeep away from heat and ignition sources
StorageStore in a cool, dry placeKeep in tightly closed containers
Personal ProtectionUse gloves, goggles, and proper ventilationAvoid contact with skin and eyes

5-Chloro-2-methylaniline is toxic and flammable. It should be handled with care, using appropriate personal protective equipment and stored in a cool, dry place away from ignition sources.

In conclusion, 5-Chloro-2-methylaniline is a valuable chemical intermediate with a wide range of applications. Its synthesis involves chlorination and methylation processes, and it is used in the production of pharmaceuticals, dyes, and agrochemicals. Proper handling and storage are essential to ensure safety in industrial and laboratory settings.

Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.


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