Introduction1. OverviewPropertyDetailsCAS Number15195-55-6Chemical Nametert-Butylhydrazine
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| Property | Details |
|---|---|
| CAS Number | 15195-55-6 |
| Chemical Name | tert-Butylhydrazine Hydrochloride |
| Synonyms | N-tert-Butylhydrazine HCl; 2-tert-Butyl-1-hydrazine hydrochloride |
| Primary Uses | Pharmaceutical intermediates, agrochemical synthesis, and organic synthesis |
| Production | tert-Butylamine condensation with hydrazine, followed by HCl salt formation |
| Attribute | Specification |
|---|---|
| Molecular Formula | C₄H₁₂N₂·HCl |
| Molecular Weight | 124.62 g/mol |
| Appearance | White to off-white crystalline powder |
| Solubility | Freely soluble in water; soluble in methanol, ethanol |
| Melting Point | 148–152°C |
| Decomposition Temp. | >180°C (with evolution of HCl) |
| Industry | Role |
|---|---|
| Pharmaceuticals | Key intermediate for antiviral drugs (e.g., remdesivir analogs) |
| Agrochemicals | Synthesis of herbicides and insecticides |
| Organic Chemistry | Building block for heterocycles (pyrazoles, triazoles) |
| Polymer Science | Chain transfer agent in polymerization reactions |
| Aspect | Guidelines |
|---|---|
| Hazard Classification | Corrosive to metals; skin/eye irritant (GHS Category 2A) |
| Storage | Inert atmosphere; cool, dry, and ventilated area (<30°C) |
| Incompatibility | Strong oxidizers, acids (may evolve HCl gas) |
| PPE | Gloves, goggles, and chemical-resistant apron |
| Region | Growth Drivers |
|---|---|
| Asia-Pacific | Expansion of generic drug manufacturing; agrochemical demand |
| Europe | Regulatory focus on sustainable synthesis routes |
| North America | Innovation in antiviral therapies; polymer additive development |
| Global Projection | Expected CAGR of 5.8% (2025–2031); driven by healthcare and agriculture |
tert-Butylhydrazine hydrochloride is a critical intermediary for high-value pharmaceuticals and crop protection agents. Its HCl salt form enhances stability and reactivity in synthesis, making it a preferred reagent in scalable processes. Market growth is underpinned by rising demand for antiviral therapies and sustainable agrochemicals, positioning this compound as a linchpin in modern chemical innovation.
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