N3-PEG4-OH (azido-tetraethylene glycol-hydroxy) CAS NO.: 86770-67-4—Focus on PEG derivatives

N3-PEG4-OH (azido-tetraethylene glycol-hydroxy) CAS NO.: 86770-67-4. This product, also known as 2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethanol, is a PROTAC linker with unique properties. It belongs to the PEG class and can be used to synthesize PROTAC (proteolysis-targeting chimeras).

N3-PEG4-OH is made from tetraethylene glycol through two-step purification. In this process, tetraethylene glycol undergoes a series of reactions and purifications, and finally becomes a high-purity, high-performance pharmaceutical intermediate in our hands. Its unique structure makes it an efficient PROTAC linker, connecting the ligand of the E3 ubiquitin ligase and the ligand of the target protein together, thereby constructing PROTACs with high selectivity and degradation activity.

The characteristic of N3-PEG4-OH is that it contains a monodisperse PEG linker with an azide (N3) and a terminal hydroxyl group. The N3 group is famous for its excellent ability to react with alkynes, BCN, DBCO, etc. It can produce stable triazole bonds, which makes it possible to connect biomolecules efficiently. In addition, the terminal hydroxyl group is highly reactive and can be further derivatized or replaced with other reactive functional groups, which makes it have significant advantages in biomolecule functionalization and drug delivery.

In addition, the presence of hydrophilic PEG spacer increases the solubility of N3-PEG4-OH in aqueous media, which facilitates its application in drug release, nanotechnology, new materials research and other fields.

【Product Information】

English name: N3-PEG4-OH

CAS NO.: 86770-67-4

English alias: Azido-PEG4-Hydroxy

Azido-PEG4-alcohol

11-Azido-3,6,9-trioxaundecanolsolution

1-Azido-3,6,9-trioxaundecan-11-olsolution

2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethanolsolution

2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethanol

Purity: ≥95%

Molecular formula: C8H17N3O4

Molecular weight: 219.238