Fmoc-L-alpha-phenylglycine

Fmoc-L-alpha-phenylglycine - Names and Identifiers

Name	Fmoc-L-alpha-phenylglycine
Synonyms	Fmoc-Phg-OH Fmoc-L-phenylglycine FMoc-(S)-phenylglycine Fmoc-L-alpha-phenylglycine (S)-Fmoc-2-aminophenylacetic acid FMoc-Phg-OH FMoc-L-phenylglycine N-Fmoc-L-2-phenylglycineFmoc-Phg-OH [(9H-Fluoren-9-ylmethoxycarbonylamino)]phenylacetic acid (3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}phenyl)acetic acid (2R)-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)ethanoic acid (2S)-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)ethanoic acid (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-2-phenylacetic acid
CAS	102410-65-1
EINECS	1533716-785-6
InChI	InChI=1/C23H19NO4/c25-22(26)13-15-6-5-7-16(12-15)24-23(27)28-14-21-19-10-3-1-8-17(19)18-9-2-4-11-20(18)21/h1-12,21H,13-14H2,(H,24,27)(H,25,26)

Fmoc-L-alpha-phenylglycine - Physico-chemical Properties

Molecular Formula	C23H19NO4
Molar Mass	373.4
Density	1.299±0.06 g/cm3(Predicted)
Melting Point	175-180°C
Boling Point	606.3±50.0 °C(Predicted)
Specific Rotation(α)	81 º (c=1% in DMF)
Flash Point	291.103°C
Solubility	soluble in Methanol
Vapor Presure	0mmHg at 25°C
Appearance	White crystal
Color	White to Almost white
BRN	5309005
pKa	3.39±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	81 ° (C=1, DMF)
MDL	MFCD00155632

Fmoc-L-alpha-phenylglycine - Risk and Safety

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
FLUKA BRAND F CODES	10
HS Code	2924 29 70
Hazard Class	IRRITANT

Fmoc-L-alpha-phenylglycine - Introduction

Fmoc-L-Phenylglycine is a compound with the chemical formula C28H22N2O5 and a molecular weight of 470.49g/mol. It is an organic amine acid derivative and has important application value.

Fmoc-L-Phenylglycine is commonly used in solid-phase synthesis as part of a synthetic polypeptide chain. It can be synthesized by a solid phase amino acid synthesis method. Solid phase synthesis is a commonly used method of peptide synthesis, in which the amino acids are sequentially fixed on the solid phase material, and the chemical reaction is repeated to construct the polypeptide chain step by step. Fmoc-L-phenylglycine is one of the selective protecting groups (protective group), which can protect the reactivity of the amino group during the synthesis.

For safety information, Fmoc-L-phenylglycine should be stored under dry, dark, low temperature conditions. During operation, attention should be paid to avoid contact with skin and eyes, and good laboratory operating habits and personal protective measures should be maintained. If inhaled, ingested, or in contact with skin, consult a doctor and bring the appropriate Chemical Safety Data Sheet (CSDS).

To sum up, Fmoc-L-phenylglycine is an organic amine acid derivative commonly used in solid-phase synthesis, which has important application value. In chemical synthesis, attention should be paid to safe use and correct operating procedures should be followed.