L-histidine dihydrochloride - Names and IdentifiersNameL-histidine dihydrochlorideSynonymsCCRIS
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| Name | L-histidine dihydrochloride |
| Synonyms | CCRIS 7814 H-His-OH.xHCl Crystalline2HCl histidine hydrochloride L-Histidine hydrochloride L-HISTIDINE DIHYDROCHLORIDE L-histidine dihydrochloride L-histidine monohydrochloride L-Histidine hydrochloride solution 1-carboxy-2-(1H-imidazol-5-yl)ethanaminium chloride 2-{[4-(1-methylethyl)phenyl]methylidene}-3-oxo-2,3-dihydro-1-benzofuran-6-yl cyclohexanecarboxylate |
| CAS | 1007-42-7 645-35-2 7048-02-4 |
| EINECS | 213-754-2 |
| InChI | InChI=1/C6H9N3O2.ClH/c7-5(6(10)11)1-4-2-8-3-9-4;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H |
| Molecular Formula | C6H10ClN3O2 |
| Molar Mass | 191.62 |
| Melting Point | 240-245°C (dec.) |
| Boling Point | 458.9°C at 760 mmHg |
| Specific Rotation(α) | [α]D20 +7.0～+10.0°(c=2,HCl) |
| Flash Point | 231.3°C |
| Solubility | Easily soluble in formic acid, soluble in water, insoluble in ethanol and B |
| Vapor Presure | 3.25E-09mmHg at 25°C |
| Appearance | White crystal or crystalline powder |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD00064556 |
| Physical and Chemical Properties | White crystalline substance; Soluble in water, acidic aqueous solution, insoluble in ethanol, ether and chloroform; Decomposition point of 245 ℃; specific rotation [α]20D 47.6 °(0.5-2 mg/mL in H2O);[α]25D 8.5 °(0.5-2 mg/mL, 6 mol/L HCl). |
| Use | For biochemical research, medicine used for the treatment of anemia and angina, aortitis, heart failure and other cardiovascular diseases, can also be used for the auxiliary treatment of peptic ulcer. Used as pharmaceutical raw materials and food additives |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 1789 8/PG 3 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10 |
| Reference | 1. [IF=3.398] Hao Zhang et al."α-Glucosidase-Mediated Glucometer Readout for Portable Monitoring of Acarbose and Migliol."Chemosensors. 2022 Jun;10(6):198 |
| traits | white crystalline substance |
| properties | white crystalline substance; Soluble in water, acidic in aqueous solution, insoluble in ethanol, ether and chloroform; The decomposition point is 245 ℃; The specific rotation [α]20D 47.6 (0.5-2 mg/ml,H2O);[α]25D 8.5 (0.5-2 mg/ml,6 mol/L HCl). |
| uses | the main components of amino acid drugs, amino acid infusion and comprehensive amino acid preparations; It is used for adjuvant treatment of peptic ulcer. Anemia, aortitis, cardiac insufficiency and other cardiovascular diseases; nutritional supplements, the synthesis speed in the human body is slow, quasi-essential amino acids, can be used to strengthen infant food, after surgery patient food. Used in biochemical research, used in medicine to treat anemia and angina pectoris, aortitis, cardiac insufficiency and other cardiovascular diseases, and can also be used for adjuvant treatment of peptic ulcers. Used as pharmaceutical raw materials and food additives |
| production method | hemoglobin is used as raw material, hydrolyzed with hydrochloric acid, separated by column chromatography with ion exchange resin, and then recrystallized with hydrochloric acid. |
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