fmoc-N-methyl-D-valine

fmoc-N-methyl-D-valine - Names and Identifiers

Name	fmoc-N-methyl-D-valine
Synonyms	Fmoc-N-Me-D-Val-OH Fmoc-D-N-Me-Ala-OH Fmoc-D-N-Me-Val-OH fmoc-N-methyl-D-valine N-ALPHA-FMOC-N-ALPHA-METHYL-D-VALINE N-(9-Fluorenylmethyloxycarbonyl)-N-methyl-D-valine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-valine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-D-VALINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-D-VALINE (R)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)(Methyl)aMino)-3-Methylbutanoic acid
CAS	103478-58-6
InChI	InChI=1/C21H23NO4/c1-13(2)19(20(23)24)22(3)21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,12H2,1-3H3,(H,23,24)/t19-/m1/s1

fmoc-N-methyl-D-valine - Physico-chemical Properties

Molecular Formula	C21H23NO4
Molar Mass	353.41
Density	1.214±0.06 g/cm3(Predicted)
Boling Point	527.6±29.0 °C(Predicted)
Flash Point	272.9°C
Vapor Presure	5.83E-12mmHg at 25°C
Appearance	Solid
pKa	3.92±0.10(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.587
MDL	MFCD00153396

fmoc-N-methyl-D-valine - Risk and Safety

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
FLUKA BRAND F CODES	10
Hazard Class	IRRITANT

fmoc-N-methyl-D-valine - Introduction

Fmoc-N-Methyl-D-Valine is a chemical compound with the following properties:

1. Appearance: A white to light yellow crystalline solid.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF), dichloromethane, methanol, etc.
3. Stability: It is relatively stable at room temperature, but it will decompose under high temperature, strong acid or strong alkali conditions.

Fmoc-N-methyl-D-valine is commonly used in the field of biochemistry and medicinal chemistry, the main uses include:

1. Peptide synthesis: As a protecting group in peptide synthesis, the hydroxyl functional group of D-valine is protected so that the peptide chain can be selectively synthesized during the synthesis process.
2. drug research and development: as a synthetic intermediate of active peptides or proteins, it is often used in the research and development and synthesis of new drugs.

The preparation of Fmoc-N-methyl-D-valine can generally be carried out by the following steps:

1. Reaction of N-methyl-D-valine with Fmoc-chloroformate to give Fmoc-N-methyl-D-valine ester.
2. Fmoc-N-methyl-D-valine ester is then reacted with a base (such as triethylamine) or an amino acid coupling reagent to generate Fmoc-N-methyl-D-valine.

Regarding safety information, Fmoc-N-methyl-D-valine is irritating. It is recommended to wear appropriate protective equipment during operation and avoid contact with skin and eyes. At the same time, pay attention to avoid high temperature, fire source and strong acid and alkali conditions during use or storage.