ethyl 5-amino-6-methylnicotinate CAS 1008138-73-5

ethyl 5-amino-6-methylnicotinate - Names and Identifiers

Name	ethyl 5-amino-6-methylnicotinate
Synonyms	5-aMino-6-Methyl-3-Pyridi... ethyl 5-aMino-6-Methylnicotinate ethyl 5-amino-6-methylnicotinate ethyl 5-amino-6-methylpyridine-3-carboxylate 5-aMino-6-Methyl-3-Pyridinecarboxylic acid ethyl ester 3-Pyridinecarboxylic acid, 5-amino-6-methyl-, ethyl ester
CAS	1008138-73-5

ethyl 5-amino-6-methylnicotinate - Physico-chemical Properties

Molecular Formula	C9H12N2O2
Molar Mass	180.2
Density	1.158±0.06 g/cm3(Predicted)
Boling Point	327.9±37.0 °C(Predicted)
pKa	4.95±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

ethyl 5-amino-6-methylnicotinate - Introduction

5-Amino -6-methyl-nicotinic acid ethyl ester is an organic compound with the chemical formula C8H12N2O2. The following is a description of its nature, use, formulation and safety information:

Nature:
5-Amino -6-methyl-nicotinic acid ethyl ester is a colorless to slightly yellow solid with a faint ammonia odor. It is soluble in water and many organic solvents, such as ethanol and chloroform. It is stable under acidic conditions but undergoes hydrolysis under strongly basic conditions.

Use:
5-amino -6-methyl-nicotinic acid ethyl ester is commonly used as pharmaceutical intermediates and biological dyes synthetic raw materials. It is used in the medical field to synthesize drugs for the treatment of hypertension, such as esomidine and losartan. In addition, it can also be used as a raw material for the synthesis of acid dyes for the dyes, coatings and plastics industries.

Preparation Method:
5-Amino -6-methyl-nicotinic acid ethyl ester can be obtained by reacting n-propylamine with methyl ethyl nicotinate under acidic conditions. Specific synthetic methods can refer to organic synthetic chemistry handbook or professional literature.

Safety Information:
When using and handling 5-amino -6-methyl-nicotinic acid ethyl ester, it is necessary to strictly follow laboratory safety procedures. It may be irritating to the eyes, skin and respiratory tract, so care should be taken to avoid contact. Appropriate protective gloves, glasses and masks should be worn during handling. If inhaled or exposed to the compound, immediately rinse the affected area with clean water and seek medical attention. During storage and transportation, it should be kept in a dry, cool and well-ventilated place, away from fire and combustibles.